Schedule 1
What this tool helps you do
This plotter estimates how repeated semaglutide, tirzepatide, or retatrutide doses overlap over time.
It uses a one-compartment model with first-order absorption and lets you compare separate lines or view combined exposure.
How it works
Method
Turn schedules into dose events
Each schedule has a compound, dose, day offset, start week, end week, and frequency in days.
Those schedule settings are expanded into individual dose events across the selected graph duration.
Method
Calculate an amount-like signal over time
Each event is modeled with a Bateman-style curve using half-life, bioavailability, volume of distribution, and time-to-peak assumptions.
The displayed y-value is not raw concentration but a concentration-derived amount-like proxy, which is better treated as a relative exposure signal.
Formula or method
ke = ln(2) ÷ half-life
ka is solved from tmax and ke
If ka ≈ ke: amount proxy = F × dose × ka × t × exp(-ke × t)
Otherwise: concentration = F × dose × ka ÷ (Vd × (ka − ke)) × (e^(−ke×t) − e^(−ka×t))
Example
A schedule from week 1 to week 4 with a 7-day frequency creates dose events on days 0, 7, 14, and 21.
In compare mode, duplicate schedules stay as separate lines; in accumulate mode, their exposure is summed.
Assumptions and limitations
This is an educational visualization tool, not a validated clinical PK simulator.
It must not be used for dose equivalence, medication switching, or individualized treatment decisions.
Source review
Reviewed
Glone Source Review Team
Public-source fact checking for GLP-1 content
See the medical review policy and reviewer profile here.
FAQ
Not exactly. It shows an amount-like exposure proxy derived from a concentration model, which is best treated as a relative signal.
You can compare schedule patterns visually, but the chart is not a dose-equivalence calculator.
Yes. The page can serialize schedules into URL parameters so the exact setup can be shared.
Sources
method
Glone planning tool methodology
How Glone documents interpolation, label-based branching, modeled curves, schedule generation, and plotted exposure estimates.
reference
Semaglutide clinical pharmacology review
Public source for semaglutide PK framing.
reference
Tirzepatide clinical pharmacology review
Public source for tirzepatide PK framing.
Important notes
These tools provide educational estimates and do not replace individualized medical advice.
Population-average curves and label rules do not capture every person, formulation, or clinical scenario.
Learn more about how Glone handles content quality in the editorial policy.
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Wegovy vs Ozempic: Key Differences Explained
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